Santa narrates the story of Buddy's travels to New York City to meet the father he never knew he had. Along the way his unrelenting cheer transforms the lives of everyone he meets and opens his father's eyes to the magic of Christmas.

The villains of the Kids Next Door, lead by Father, join forces to resurrect the Ultimate Evil, Grandfather, a tyrant who once ruled the world many years ago when most of the villains were themselves kids. However, Father disgraced him that he can't even try to destroy the KND and the Villains were quickly betrayed when they are turned into Senior Citizombies, creatures that are immortal and can transform any living creature into one of them and slaves who are forced to make Tapioca to refuel Grandfather so he can find and destroy the Book of K.N.D.

The American Dad short film, which preceded the theatrical run of the 2005 feature Fever Pitch, is about Stan Smith touring his work days in the CIA and his "normal" everyday life.

Irwin, Hoss Delgado, Jeff the Spider, Fred Fredburger, and General Skarr from the "Grim Adventures of Billy and Mandy" team up to fight an evil candy army from the Underworld on Halloween.

The series focuses on an eccentric motley crew that is the Smith family and their three housemates: Father, husband, and breadwinner Stan Smith; his better half housewife, Francine Smith; their college-aged daughter, Hayley Smith; and their high-school-aged son, Steve Smith. Outside of the Smith family, there are three additional main characters, including Hayley's boyfriend turned husband, Jeff Fischer; the family's man-in-a-goldfish-body pet, Klaus; and most notably the family's zany alien, Roger, who is "full of masquerades, brazenness, and shocking antics."

The maniacal baby of the Griffin family, Stewie, meets his future self. In doing this he discovers that his future image is not what he has anticipated because of a near death experience.