Wendell Lawson has only six months to live. Not wanting to endure his last few months of life waiting for the end, he decides to take matters into his own hands and enlists the help of a delusional mental patient to help him commit suicide.

Charlie, Itchy and Sasha itch and scratch their way through everything and anything in an effort to save Christmas from the wicked hellhound Belladonna, who wants to use dogs from all over the world to ruin Christmas.

A rookie FBI agent, Jo Dee Foster (Billy Zane), has been assigned to work on the case of the Psycho Killer, a killer who has killed over 120 people. But to find out more about the Psycho Killer, Jo is forced to meet Dr. Animal Cannibal Pizza (Dom DeLuise), a famous doctor turned cannibal who ate pizzas with human body parts. Meanwhile, Jo's girlfriend, Jane Wine (Charlene Tilton), has just stolen $400,000 in cash from her money-hungry boss, Mr. Laurel (Rip Taylor), so she and Jo can be happy, but gets lost in a really horrible storm, caused mostly by a special effects crew behind her car, and stops at the Cemetery Motel, where the owner, Antonio Motel (Ezio Greggio), is dominated by his insane mother ('Shelly Winters').

Some time after the Mousekewitz's have settled in America, they find that they are still having problems with the threat of cats. That makes them eager to try another home out in the west, where they are promised that mice and cats live in peace. Unfortunately, the one making this claim is an oily con artist named Cat R. Waul who is intent on his own sinister plan. Unaware of this, the Mousekewitz's begin their journey west, while their true cat friend, Tiger, follows intent on following his girlfriend gone in the same direction.

A widowed field mouse must move her family -- including an ailing son -- to escape a farmer's plow. Aided by a crow and a pack of superintelligent, escaped lab rats, the brave mother struggles to transplant her home to firmer ground.