Bud and Doyle are two losers who are doing nothing with their lives. Both of their girlfriends are actively involved in saving the environment, but the two friends couldn't care less about saving the Earth. One day, when a group of scientists begin a mission to live inside a "Bio-Dome" for a year without outside contact, Bud and Doyle mistakenly become part of the project themselves.

Rhode Island State Trooper Charlie Baileygates has a multiple personality disorder. One personality is crazy and aggressive, while the other is more friendly and laid back. Both of these personalities fall in love with the same woman named Irene after Charlie loses his medication.

Tony Lip, a bouncer in 1962, is hired to drive pianist Don Shirley on a tour through the Deep South in the days when African Americans, forced to find alternate accommodations and services due to segregation laws below the Mason-Dixon Line, relied on a guide called The Negro Motorist Green Book.