The story opens in a Western saloon, where a young musician with a banjo begins to tell a tale of Lucky Luke and his sworn enemies the Dalton brothers: Joe, William, Jack and Averell. Luke has, once again, as he has done many times before, thrown the four outlaws into jail. The prison is also the abode of a guard dog named Rin Tin Can (Rantanplan in the original French language version).

Asterix and Obelix depart on an adventure to complete twelve impossible tasks to prove to Caesar that they are as strong as the Gods. You'll roar with laughter as they outwit, outrun, and generally outrage the very people who are trying to prove them "only human".

Due to an unfortunate accident involving Obelix throwing a menhir, Getafix the druid not only loses his memory, but goes completely mad. Now deprived of the wisdom of their beloved druid and the protection provided by his magic potion, the Armorican village falls prey to a proclaimed soothsayer who comes with ominous predictions and overweening ambitions. It's up to Asterix to keep his villager friends within reason and hopefully get Getafix to remember the magic potion's recipe before the impending Roman attack.