A quiet, stoic man, lives a monk-like existence in self-imposed exile. When his estranged son is killed in a drug deal gone bad, he is left to look after a granddaughter he never knew existed, and he is forced back into a life he tried to put behind him.

A family of four are suddenly sealed inside their home with no way out, and must work together to survive against both their dwindling resources and the mysterious, looming threat that is keeping them trapped.

A top-tier Canadian virologist and his Chinese wife are suddenly arrested by military secret agents in Beijing. He is threatened with the task of stealing a sample of his own work from his former laboratory, and the situation rapidly turns worse when people begin to fall ill.