Twenty years have gone by since we last saw Malcolm and his family — and after all that time, they've learned absolutely nothing.

Medium Sylvia Pickel and psychometrist Nick Deezy meet at a psychic research facility in New York. Not long after, they're contacted by Harry Buscafusco, who offers them $50,000 to find his lost son in South America, in the heart of Incan territory where they discover an ancient mystical secret, and each other.

Big Bird is sent to live far from Sesame Street by a pesky social worker, who thinks it would be better for him to live with other birds. Unhappy, Big Bird runs away from his foster home, prompting the rest of the Sesame Street gang to go on a cross-country journey to find him.

Womanising, right-wing Dan Hanson and quiet, liberal Lorie Bryer work for the Baltimore Sun. Rivals for the job of new writer of a vacant column, the paper ends up instead printing their very different opinions alongside each other, which leads to a similarly combative local TV show. At the same time their initial indifference to each other looks like it may evolve into something more romantic.

A small-town news reporter and a Greenpeace volunteer enlist the help of rival superpowers to save three majestic gray whales trapped under the ice of the Arctic Circle.

Hotel manager Robert Grant is forced by his boss to postpone his family vacation when a hotel critic checks in. Trouble is, the critic is really a villainous jewel thief with an orangutan assistant named Dunston. When Dunston gets loose and tries to escape a life of crime -- aided by Robert's sons -- havoc, hijinks and lots of laughs abound!

The season marked the move of main character Jim Halpert from Scranton to Stamford, and also introduced Rashida Jones as Karen Filippelli, and Ed Helms as Andy Bernard—both members of Dunder Mifflin Stamford—as recurring characters. The main plot for the early episodes of the season deals with a recurring problem in seasons one and two—the problem of company downsizing—while in the last half of the season, inter-office relationships also became a major plot point.

GiGi(Ginnifer Goodwin 饰)是个对爱情充满幻想的女孩儿，却在一次次约会中受挫。她的闺蜜Beth（Jennifer Aniston 饰）和Janine（Jennifer Connelly 饰）不断鼓励GiGi在感情中振奋起来，却各自对爱情怀有遗憾。Beth与Neil（Ben Affleck 饰）同居七年，却一直未能等来期待的那枚婚戒。Janine的敏感让她与Ben（Bradley Cooper 饰）的婚姻陷入僵局，而Ben与歌手Anna（Scarlett Johansson 饰）的婚外情更是给他们的婚姻雪上加霜。Anna一边拒绝拥趸Conor（Kevin Connolly 饰）的示好，一边热情似火的期待Ben离开Janine，可是Ben真的能离开Janine来到她的身边么？另一方面Anna的好友Mary（Drew Barrymore 饰）在一个清晨和Conor面对面的不期而遇了。
几个女孩儿带着爱情的梦想在城市中跌跌撞撞，而此时一直未遇真爱的GiGi在酒吧老板Alex（Justin Long 饰）的口中听到了让所有女人心碎的话“He is just not that into you!”