ZOMBEX tells the story of a post-Katrina New Orleans as it deals with a new disaster, a zombie apocalypse. NOLA residents are no longer experiencing the depression and post-traumatic stress due to the trauma of the hurricane, thanks to the revolutionary ZOMBEX - a rogue, yet, "clinically-proven" anti-depressant pharmaceutical manufactured by a nefarious organization. For those who call the Big Easy their home, everything is just now turning around for them. Or, could it just be the drug, ZOMBEX, talking... Just as things are turning around for the city and its people, they once again must face a disaster of epic proportions. Only this time, they're dealing with the prospect of losing the people of New Orleans as they turn into the city's walking dead.

The "Devil's Evil Guitar" has been removed from the world by the supreme being, and rock and roll is a thing of the past in this newly puritanical environment. But what happens when the guitar is sent back by Vicious, an angel punk?

The film discusses the traits and originators of some of metal's many subgenres, including the New Wave of British Heavy Metal, power metal, Nu metal, glam metal, thrash metal, black metal, and death metal. Dunn uses a family-tree-type flowchart to document some of the most popular metal subgenres. The film also explores various aspects of heavy metal culture.