Lifelong friends and medical school graduates Mary Stevens and Don Andrews decide to set up office together. While Mary struggles to earn respect because of her gender, Don gets caught up in his ambitions for a bigger life.

World War I veteran Tom Holmes is marked by the unbearable suffering caused by his battle wounds. Over the years, he comes to experience both the pain of misfortune and a love for other human beings.

Dr. Socrates gave up his brilliant career as surgeon in a prominent hospital because his betrothed died under his knife. He is now a struggling doctor in a small town that has a gangster's hideout.

A hustling public relations man promotes a series of fads.