After Season 5’s explosive finish, everything is up in the air for the survivors of flight 815. No one knows what — or who — the future will hold. Will Juliet’s sacrifice to save her friends work? Can Kate choose, once and for all, between Jack and Sawyer? Will Sun and Jin be reunited? Is it too late to save Claire? Whatever awaits everyone on the island, one thing is for certain — the moment of truth has arrived.

在芸芸众生之中，有一类人被称为“阿尔法人”，由于大脑结构产生了变异，这些阿尔法人因而获得了常人无法拥有的超能力，却也因此成为了政府的“眼中钉”，于是，一个专门针对阿尔法人存在的秘密组织成立了。
格雷（瑞安·卡怀特 Ryan Cartwright 饰）性格自闭但拥有远远超越了电脑的信息处理能力，比尔（马利克·约巴 Malik Yoba 饰）能够在短时间内强化身体肌肉获得过人的力量，妮娜（劳拉·门内尔 Laura Mennell 饰）外表美艳，善于操纵人心，瑞秋（阿齐塔·贾尼札达 Azita Ghanizada 饰）善于将声波化为利刃，威力无比。就是这样四位“阿尔法人”，他们和秘密组织的领头人罗森（大卫·斯特雷泽恩 David Strathairn 饰）相遇了。

Picking up from the shocking Season 3 finale, learn via "flash forwards" who from Oceanic Airlines flight 815 gets off the island.

An invisible and mysterious force field descends upon a small fictional town in the United States, trapping residents inside, cut off from the rest of civilization. The trapped townsfolk must discover the secrets and purpose of the "dome" and its origins, while coming to learn more than they ever knew about each other.

The castaways continue to seek strength as paranoia increases, prompting the revelation of more backstories -- and more secrets about the island.

The motley crew of castaways remains stranded on the eerie deserted island populated by mysterious things that go bump in the night.

该剧根据史蒂夫-金的同名畅销书改编，著名制片人David E. Kelley担任剧集总监，Jack Bender参与制片并执导首集。
故事描述一个疯狂的杀手用一系列可怕的信件和电子邮件来嘲弄一个退了休的警探，迫使这名警探私下展开调查行动。他发誓要将穷凶极恶的杀手绳之以法 ，以免他再次作案害人。Brendan Gleeson扮演主人公Bill Hodges侦探，在一个宿敌再次出现后被迫「结束」退休。Harry Treadaway扮演精神错乱的冰淇淋卡车司机Brady Hartsfield，同时是网络巡警的IT人员。事实上，他就是臭名昭著的「梅赛德斯杀手」。
原著2014年6月出版，直接冲上《纽约时报》畅销书排行榜，并且赢得了爱伦坡最佳小说奖。史蒂芬-金计划撰写三部曲，《梅赛德斯先生》只是其中的第一本书。第二本书《捡到归我》（Finders Keepers）去年6月出版，第三本书《End of Watch》今年6月7日出版。

Following the shocking developments at the conclusion of season five, survivors from all parts of Westeros and Essos regroup to press forward, inexorably, towards their uncertain individual fates. Familiar faces will forge new alliances to bolster their strategic chances at survival, while new characters will emerge to challenge the balance of power in the east, west, north and south.