该剧取材自自哥伦比亚女商人Griselda Blanco（索菲娅·维加拉 Sofía Vergara 饰）的真实人生故事，她不仅是一位全心全意的母亲，更是一手创建了史上最赚钱的贩毒集团之一。Griselda风采十足的外表之下暗藏狠辣手段，这让她得以兼顾家庭、叱吒商场，成为众所皆知的“黑寡妇/教母”。

《无痛杀手》是一部有脚本的限定剧集，故事情节虚构，探讨了美国阿片类药物危机的起源和后果，重点讲述了肇事者、受害者和寻求真相者的故事，他们的生活因奥施康定的发明彻底改变了。《无痛杀手》对犯罪、问责制和屡屡令数十万美国人失败的制度进行了审视，改编自巴里·迈耶的《Pain Killer》（中译本《止痛毒丸》）一书和帕特里克·拉登·基夫在《纽约客》杂志上发表的文章《The Family That Built an Empire of Pain》。监制阵容包括埃里克·纽曼、彼得·博格和亚历克斯·吉布尼，以及剧集主管/创剧人迈卡·费兹曼-布卢和诺亚·哈普斯特。主演阵容包括乌佐·阿杜巴、马修·布罗德里克、泰勒·克奇、迪纳·什瓦比和韦斯特·杜乔夫尼。

Two journalists set out to document their friend's journey to reunite with his estranged sister. They track her to an undisclosed location where they are welcomed into the remote world of "Eden Parish," a self-sustained rural utopia composed of nearly two hundred members and overseen by a mysterious leader known only as "Father." It quickly becomes evident to the newcomers that this paradise may not be as it seems. Eden Parish harbors a twisted secret. What started as just another documentary shoot soon becomes a fight for survival.

William Hundert is a passionate and principled Classics professor who finds his tightly-controlled world shaken and inexorably altered when a new student, Sedgewick Bell, walks into his classroom. What begins as a fierce battle of wills gives way to a close student-teacher relationship, but results in a life lesson for Hundert that will still haunt him a quarter of a century later.