In the final months of World War II, 14-year-old Seita and his sister Setsuko are orphaned when their mother is killed during an air raid in Kobe, Japan. After a falling out with their aunt, they move into an abandoned bomb shelter. With no surviving relatives and their emergency rations depleted, Seita and Setsuko struggle to survive.

In Italy in the 1930s, sky pirates in biplanes terrorize wealthy cruise ships as they sail the Adriatic Sea. The only pilot brave enough to stop the scourge is the mysterious Porco Rosso, a former World War I flying ace who was somehow turned into a pig during the war. As he prepares to battle the pirate crew's American ace, Porco Rosso enlists the help of spunky girl mechanic Fio Piccolo and his longtime friend Madame Gina.