第三季的焦点重回到活跃于街头的Barksdale团伙，同时也将视角扩展到政治领域。此外，本季当中引入Hamsterdam这一新支线剧情，以探讨在部分人烟稀少的街区对非法毒品交易及卖淫的「事实性」合法化会有怎么样的潜在积极作用。这种做法在阿姆斯特丹和其他欧洲城市取得了积极成果，减少了市内的街头犯罪。这些都是对早先情节的延续。

2019 film directed by Anthony Maras

Season one chronicles the rise of drug lord Pablo Escobar, the ruthless boss of the Medellin Cartel and a known terrorist who was also a congressman, a family man and revered by the poor as a new Robin Hood.

Mr. Finch (Michael Emerson), a mysterious billionaire, developed a computer program for the government that predicts terrorist threats to the US. It was designed as a means to prevent another 9/11-type disaster, but Finch discovered that it was also predicting many "irrelevant" (non-terrorist) crimes. The non-terrorist data is dumped to a separate database and deleted each night. Finch realized that a great many domestic crimes could also be prevented if that data could be used. Finch built a backdoor into the machine that allows him to retrieve a list of Social Security numbers of people who will be involved in those crimes in order of occurrence. Unable to investigate the data on his own, Finch hires John Reese (Jim Caviezel), a former Green Beret and CIA field officer who is presumed dead, to help stop the crimes from taking place. The world thinks that Finch, like Reese, is dead. Finch made the choice of only transmitting the Social Security Numbers of the persons of interest so that if the backdoor is discovered, the government would have no clue as to what the numbers mean or that Finch is still alive.