In 1958 New York, Midge Maisel’s life is on track– husband, kids, and elegant Yom Kippur dinners in their Upper West Side apartment. But when her life takes a surprise turn, she has to quickly decide what else she’s good at – and going from housewife to stand-up comic is a wild choice to everyone but her.

Midge and Susie discover that life on tour with Shy is glamorous but humbling, and they learn a lesson about show business they’ll never forget. Joel struggles to support Midge while pursuing his own dreams. Abe embraces a new mission and Rose learns she has talents of her own.