King T'Challa returns home to the reclusive, technologically advanced African nation of Wakanda to serve as his country's new leader. However, T'Challa soon finds that he is challenged for the throne by factions within his own country as well as without. Using powers reserved to Wakandan kings, T'Challa assumes the Black Panther mantle to join with ex-girlfriend Nakia, the queen-mother, his princess-kid sister, members of the Dora Milaje (the Wakandan 'special forces') and an American secret agent, to prevent Wakanda from being dragged into a world war.

本剧根据漫威漫画《What If...?》改编，用动画影集的方式去探索漫威电影宇宙中的关键时刻并将其翻转过来，探讨如果史蒂夫·罗杰斯没有接受实验，而是卡特探员成为超级战士等另一种走向，从而带领观众进入未知领域。