Police officers around Tokyo are being murdered by an unknown assailant. When Ran witnesses an attempt on the life of one of her friends in the police, she loses her memory. Now, Conan and Inspector Megure must find the murderer while Ran attempts to regain her lost memories.

As a pair of towers in Tokyo are being prepared for their grand opening, there is a series of murders of people connected to the towers. Conan suspects that the mysterious Syndicate may also be involved.

Noah's Ark—the latest in VR technology and a milestone of human innovation—is set for a showcase to Japan's privileged children. They have the honour of beginning a new revolution in gaming; however, their carefree fun is cut short when a company employee is found murdered, with his dying message pointing to a clue hidden within the Ark. Along with the Detective Boys and Ran Mouri, Conan Edogawa enters Noah's Ark to solve this mystery and ensure the perpetrator is caught. But once they're inside the Ark, it takes on a mind of its own, imprisoning them and the children within its worlds. To escape and bring the murderer to justice, Conan and company must navigate a simulated 19th century London and track down the infamous Jack the Ripper—with the lives of 50 innocent children depending on them.