剧集改编自理查德·普雷斯顿所著的有关埃博拉病毒及其对人类影响的畅销书。1989年，埃博拉病毒突然出现在华盛顿郊区一个科学实验室的黑猩猩身上，且当时并没有已知的治疗方法。英勇的美军兽医(玛格丽丝饰)与一支秘密军事特警队合作，在疫情蔓延到人类之前，她试图阻止，但这却让她陷入了致命危险。

While investigating a terroristic threat that goes viral online, Korean authorities discover that a suspect has recently boarded an international flight bound for the United States. When a healthy passenger on the same flight suddenly dies a gruesome death of unknown cause, panic erupts both in-flight and on the ground. With steadily decreasing fuel and international refusals to offer aid, the captain and crew will be forced to take unprecedented emergency measures in an attempt to save the lives of their passengers.