一间细思极恐的杂货店，专门收购神奇的东西，拯救生命的腕表，满足愿望的酒，杀人的垃圾桶，摄人魂魄的相机，闻所未闻的一切，都在这里发生……

Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.