The film revolves around a local street-racer who partners with a rich and arrogant business associate, only to find himself framed by his colleague and sent to prison. After he gets out, he joins a New York-to-Los Angeles race to get revenge. But when the ex-partner learns of the scheme, he puts a massive bounty on the racer's head, forcing him to run a cross-country gauntlet of illegal racers in all manner of supercharged vehicles.

The fast-paced action movie is again set in the criminal underworld in France, where Frank Martin is known as The Transporter, because he is the best driver and mercenary money can buy. In this installment, he meets Anna and they attempt to take down a group of ruthless Russian human traffickers who also have kidnapped Frank’s father.