A love story in reverse: How I Met Your Mother is a fresh new comedy about Ted (Josh Radnor) and how he fell in love. When Ted's best friends Marshall (Jason Segel) and Lily (Alyson Hannigan) decide to tie the knot, it sparks the search for his own Miss Right. Helping him in his quest is his bar-hopping "wing-man" Barney (Neil Patrick Harris), a confirmed bachelor with plenty of wild schemes for picking up women. Ted's sights are set on the charming and independent Robin (Cobie Smulders), but destiny may have something different in mind. Told through a series of flashbacks, Ted recalls his single days, the highs and lows of dating and the search for true love.

Deb（布鲁克·奥赛 Brooke D'Orsay 饰）是个艳冠群芳但是学识浅薄的美人，梦想自己有一天能成为超级模特，却在一次严重的交通事故中丧命。在去到天堂后，被天堂守门人Fred（本·费德曼 Ben Feldman 饰）拒之门外，就因为判定她是个性浅薄的中庸者，无法入天堂也无法去地狱。她因为和Fred起争执按动了返回人间的按钮。但是意外再次发生，她居然上错了身。进入Jane（布洛克·艾略特 Brooke Elliott 饰）的身体，一个聪明睿智、很有主见、热爱工作、忠于职守的女律师，唯一的缺点是太胖了。无可奈何的Deb只能在守护天使Fred的帮助下她开始作为Jane生活。没有了美貌的她要如何在人间生活，她又要如何才能找回自己的过去呢？