Interpol Inspector Zenigata begins a world-wide hunt for the infamous thief Lupin The 3rd. But together, they face a powerful enemy and form the Lupin team in response. The Lupin team then faces the challenge of retrieving the "Crimson Heart of Cleopatra" locked away in a fort like safe. The treasure is thought to allow its owner to control the world.

该剧改编自知名漫画家井浦秀夫的同名人气漫画原作「刑事弓神」（小学馆《Big Comic Original》[青年半月刊]连载中）。浅野忠信饰演拥有独特推理力和观察力，不带任何先入为主的观念，用敏锐眼光洞察人性的阴暗面，为了追求事实真相甚至不惜采用违法手段的的刑警弓神适当；神木隆之介饰演成绩优秀，老实认真，具有强烈正义感的新人刑警羽生虎夫。剧中羽生在弓神手下被呼来喝去，两位极具差异性的搭档将一起合作解决各种疑难案件。该剧采用一集一案件的形式呈现，每集都会有不同的豪华演员加盟。