一个政治家在目睹妻子在一起恐怖事件中死于汽车炸弹后，一直在和自己搏斗……

国际刑警组织发布名为「红色通缉令」的全球警戒，出手追捕全球头号通缉犯。一桩胆大妄为的劫案，却导致美国联邦调查局一名顶尖犯罪侧写员（道恩·强森 Dwayne Johnson 饰），杠上两位互相较劲的罪犯（盖尔·加朵 Gal Gadot、瑞安·雷诺兹 Ryan Reynolds 饰），这下事情会怎么发展，可就难说了。

卡门·圣地牙哥是位神偷，她运用自己的技艺做好事，在机灵的伙伴帮助下，踏遍世界各地阻止邪恶的国际恶联。

The Gamache, tailors from father to son, have been dressing the Mafia family Paternò for three generation. Vincent "Vince" Gamache works on behalf of Frank the godfather with his eldest son Giaco. Vince, reckless and rash, seeks to earn his stripes by impressing the godfather. Without the Paternò knowing, he stages a big operation and is promoted. Fuming with jealousy, Giaco discovers that Vince committed a monstrous act during his stroke. The Gamache disown Vince and war begins.