The 2010 show was recorded on 13 December and aired on 3 January 2011. The teams were:
Wagner: Jonathan Ross and Ruth Jones (winners with 28 points)
Posh & Specs: Michael McIntyre and Alan Carr (25 points)
The Electric Moccasins: Richard Ayoade and Noel Fielding (12 points)
Guest questions were provided by Nicole Scherzinger, Jack Black, Simon Pegg, Russell Brand, Seth Rogen, the cast of Misfits and Will Ferrell. The children of Mitchell Brook Primary School made their annual appearance acting out news stories, which included the Stig scandal and the Icelandic volcano eruption, as did Jon Snow with his fake news reports of popular songs. Lola, the cat put in a wheelie bin in August by Mary Bale appeared as a Mystery Guest. Louie Spence posed a question in the form of a dance routine representing the story of the trapped Chilean miners.

Channel 4预定四集性丑闻剧集《国家淫才》（National Treasure）。该剧虚构一个国宝级人才，因为性侵而被指控。该剧以调查案件以及开庭审判为主线，探讨加害人与受害人的心理。该剧由Jack Thorne创作，定于明年播出。新闻稿指，该剧取材于真人真事。讲述Paul Finchley曾主演现象级喜剧，广受观众喜爱，尽管淡出荧屏很多年，依然会被群众认出，是一个演艺界的国宝人才。但是，突然被揭发自上世纪70年代开始性侵女性。除了Paul受到铺天盖地媒体报道以及警方深入调查而困扰，还有出庭指控现已50岁的受害者也受到了同样待遇。