Mayme and sister Janie are salesgirls in Ginsberg's Department Store. Mayme is in love with store clerk Bill, but Janie tries to steal him from her. Hazel, another salesgirl, is Jean Harlow's first credited role.

Nancy Carroll stars in Manhattan Cocktail as Babs, a college coed who dreams of becoming a famous actress. Joining up with her campus chums Fred (Richard Arlen) and Bob (Danny O'Shea), likewise aspiring thespians, Babes heads to Broadway with stars in her eyes. The winsome threesome are quickly disillusioned by the heartless machinations of nasty producer Renov (Paul Lukas) and his harridan wife (Lilyan Tashman). Before the plot proper gets under way, the audience is regaled with a cute "mythological" prologue, featuring the same three leading actors. Manhattan Cocktail was a silent picture, except for two brief musical numbers showcasing Nancy Carroll.

Philandering actor Richard Hardell is murdered at a movie studio. His jealous wife Blanche, his director Rupert Borka, and a girl he mistreated, Helen MacDonald, all have substantial reasons for having wanted him dead.