A young woman from Las Vegas wants Perry Mason to defend her father.

Sleazy talk show host Ted Mayne writes a tell-all book, which enrages and embarrasses several very prominent women. One of them, actress Roxanne Shield, loses her composure during an interview and winds up making a televised death threat. Of course, when Ted is murdered, she is arrested. Witnesses claim they saw Roxanne outside his apartment that night and police later find the murder weapon in her car. Renowned defence attorney Perry Mason accepts the challenge of defending her in court.

David Katz is a world famous magician and he comes to Denver with his group to perform for a charity gala for disabled children. Also there is Perry and Della as all three are supporters of the charity. Kate Ford, an assistant with an arrogant attitude, tells David that she is, from now on, going to do an illusion in which an assistant is raised in a glass coffin only to disappear when the coffin is opened up in the air (while the assistant climbs out before the coffin is raised.) After a one night stand with David, Kate is pregnant and she blackmails David with this. David and his wife Judy can't have children so that comes as a double blow to them. However Kate, with her attitude, creates much hatred at her from the rest of the group. At the gala, the glass coffin is raised but when it opens Kate's dead body falls to the ground - strangled.

The owner of a cosmetics company is unveiling a new cream which she claims she's been using. She's been keeping her age a secret and now reveals that she's 60 and owes her appearance to the cream. She's later killed and the formula missing. Her husband is arrested and Perry defends him.

A priest is murdered and the main suspect is a nun.

After being away for awhile, Andy Taylor returns home to Mayberry to visit Opie, now an expectant father. While there he ends up helping Barney Fife mount a campaign for sheriff.

A brilliant attorney gets rid of her boring husband by faking his kidnapping and keeping the ransom. The FBI may be fooled, but not Columbo.