For years, Blade has fought against the vampires in the cover of the night. But now, after falling into the crosshairs of the FBI, he is forced out into the daylight, where he is driven to join forces with a clan of human vampire hunters he never knew existed—The Nightstalkers. Together with Abigail and Hannibal, two deftly trained Nightstalkers, Blade follows a trail of blood to the ancient creature that is also hunting him—the original vampire, Dracula.

With his eye on a lovely aristocrat, a gifted illusionist named Eisenheim uses his powers to win her away from her betrothed, a crown prince. But Eisenheim's scheme creates tumult within the monarchy and ignites the suspicion of a dogged inspector.

Factory worker Doug Quaid takes a virtual mind-trip vacation with the Rekall company, opting for implanted memories of being a spy. When the procedure goes wrong, Quaid becomes a wanted man by the police and joins forces with a rebel fighter to stop the evil Chancellor Cohaagen.