Tien Xiao-Xiang is a fan of author Si-Yi and Tarot cards. But deep down, she has another love, childhood sweetheart Li Zhu-Hao. Just when she sees the perfect opportunity to reveal her love to him from fortunetelling, Li Zhu-Hao confesses his feelings to her best friend Song Yi-Jing! But Song Yi-Jing has a condition for Li Zhu-Hao, that is to help three couples to date. They are: aloof and misandric art professor Stone and lovesick gym owner Liu Zhi-Liang; the most unpopular weirdo in school, Ah-Yu, and the subject of her nonstop public displays of love, campus hunk Danny Lo; mob boss lady Yu and philosophy student Ah-Shan. To make it happen for these three unlikely couples is almost like mission impossible.

年近33岁的单无双（杨谨华 饰）至今未婚，仅有的热情只能倾入到无限的工作中。然而年纪越来越大，机会却越来越少，单无双不甘心就这样孤独终老。耶诞夜追新闻赶头条抢了“耶诞老人”的自行车，不料“耶诞老人”的大白胡子下却是一张英俊的脸，此人便是网络盛传的“事事达”打工达人卢卡斯（阮经天 饰）。意外的是卢卡斯居然是单无双的邻居，又莫名其妙的成为他的保镖兼助理，两人相处中居然互生好感，可是挡在他们中间的除了卢卡斯不能忘却的旧恋，还有相差8岁的事实。败犬女王遭遇打工达人，谱写了一出温馨浪漫的恋爱进行曲。
姐弟恋的情节，妙趣横生的对白以及谐诙幽默的表演，构成该剧吸引观众的三大法宝，台湾“偶像剧一哥”阮经天的加盟更为该剧赚足眼球。据悉，《败犬女王》在台湾平均收视率达5.69。