Legless Southern inventor Dr. Arliss Loveless plans to rekindle the Civil War by assassinating President U.S. Grant. Only two men can stop him: gunfighter James West and master-of-disguise and inventor Artemus Gordon. The two must team up to thwart Loveless' plans.

Robert Neville is a scientist who was unable to stop the spread of the terrible virus that was incurable and man-made. Immune, Neville is now the last human survivor in what is left of New York City and perhaps the world. For three years, Neville has faithfully sent out daily radio messages, desperate to find any other survivors who might be out there. But he is not alone.