Masaki, a baseball player and gas-station attendant, gets into trouble with the local Yakuza and goes to Okinawa to get a gun to defend himself. There he meets Uehara, a tough gangster, who is in serious debt to the yakuza and planning revenge.

Ashitaka, a prince of the disappearing Emishi people, is cursed by a demonized boar god and must journey to the west to find a cure. Along the way, he encounters San, a young human woman fighting to protect the forest, and Lady Eboshi, who is trying to destroy it. Ashitaka must find a way to bring balance to this conflict.