With only three weeks left in his three year contract, Sam Bell is getting anxious to finally return to Earth. He is the only occupant of a Moon-based manufacturing facility along with his computer and assistant, GERTY. When he has an accident however, he wakens to find that he is not alone.

In the 22nd century, a paraplegic Marine is dispatched to the moon Pandora on a unique mission, but becomes torn between following orders and protecting an alien civilization.

Dr. Ryan Stone, a brilliant medical engineer on her first Shuttle mission, with veteran astronaut Matt Kowalsky in command of his last flight before retiring. But on a seemingly routine spacewalk, disaster strikes. The Shuttle is destroyed, leaving Stone and Kowalsky completely alone-tethered to nothing but each other and spiraling out into the blackness of space. The deafening silence tells them they have lost any link to Earth and any chance for rescue. As fear turns to panic, every gulp of air eats away at what little oxygen is left. But the only way home may be to go further out into the terrifying expanse of space.

The adventures of a group of explorers who make use of a newly discovered wormhole to surpass the limitations on human space travel and conquer the vast distances involved in an interstellar voyage.